paracrine interactions between adipocytes and tumor

GUPEA: Metabolic and immunological interactions between

Paracrine: Abstract: Triple-negative breast cancers have fewer treatment options than other breast cancers The overall goal of this research is to identify new pharmaceutical targets for triple-negative breast cancer through studies of the tumor-promoting crosstalk between tumor and

Recent advances in understanding tumor stroma

Mar 30 2019Although solid tumors comprise malignant cells they also contain many different non-malignant cell types in their micro-environment The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts The bi-directional interactions between tumor and stromal cells

Human adipocyte extracellular vesicles in reciprocal

Dec 12 2013Objective Extracellular vesicles (EVs) released by human adipocytes or adipose tissue (AT)‐explants play a role in the paracrine interaction between adipocytes and macrophages a key mechanism in AT inflammation leading to metabolic complications like insulin resistance (IR)

The critical roles of activated

Feb 19 2018For example miR-210 was reported to regulate the interactions between PSCs and PDA cells via ERK and Akt pathways Moreover recent studies validated that miR-199a and miR-214 are upregulated in patient-derived pancreatic PSCs and targeting them caused the dedifferentiation of aPSCs and inhibited tumor-promoting paracrine effects

An

Jun 14 2012Stromal–epithelial interactions play an integral role in regulating tumor development in the mammary gland 1 2 To address the complexity of these interactions the establishment of a 3D tissue culture model is essential for understanding the inter‐relationship between the epithelial cells and the breast stroma Previous evidence supports the vital role of the local environment in

A Proximal Culture Method to Study Paracrine Signaling

Productive paracrine and juxtacrine interactions with the mesothelial cells help in inducing adaptive responses in the ovarian cancer cells which enable successful metastasis 17 18 20 21 To test the effectiveness of the proximal culture method we tested the paracrine interactions between HeyA8 ovarian cancer cells and HPMCs

Frontiers

Apr 28 2020Introduction Adipocytes are one of the primary stromal cells present in multiple cancers such as breast ovarian and colorectal cancer (Nieman et al 2011 Wu et al 2019a) Specifically cancer-associated adipocytes (CAAs) are considered to play an active role in the tumor microenvironment

Paracrine signaling

Although paracrine signaling elicits a diverse array of responses in the induced cells most paracrine factors utilize a relatively streamlined set of receptors and pathways In fact different organs in the body - even between different species - are known to utilize a similar sets of paracrine factors in differential development The highly conserved receptors and pathways can be organized

Breast cancer mammospheres secrete Adrenomedullin to

expression in adipocytes Conclusions: Breast tumor cells secreted ADM that modified cancer–associated adipocytes through paracrine signaling leading to metabolic changes and delipidation Hence ADM appears to be crucial in controlling the interactions between cancer cells and adipocytes and represents an excellent target to hinder them

Recent advances in understanding tumor stroma

Mar 30 2019Although solid tumors comprise malignant cells they also contain many different non-malignant cell types in their micro-environment The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts The bi-directional interactions between tumor and stromal cells

Butyrate Attenuates Inflammation and Lipolysis Generated

Aim: Paracrine interaction between macrophages and adipocytes in obese visceral fat tissues is thought to be a trigger of chronic inflammation The immunomodulatory effect of the short chain fatty acid butyric acid has been demonstrated We hypothesize that sodium butyrate (butyrate) attenuates

Local adipocyte cancer cell paracrine loop: can sick fat

In addition to systemic effects their tumor-promoting impact is dependent on local functions notably via a complex adipocyte cancer cell paracrine loop (ACCPL) Indeed this event leads to dramatic phenotypic and/or functional modifications of both cell types as well as of the extracellular matrix

Adipocyte lipolysis links obesity to breast cancer growth

Jan 13 2017Breast cancer cells stimulate lipolysis in mature 3T3-L1 adipocytes and accumulate adipocyte-derived fatty acids A number of studies have described reciprocal crosstalk between cancer cells and stromal adipocytes but these have largely focused on endocrine and paracrine signaling mechanisms (see review []) To determine direct functional effects of breast cancer cells on adipocyte

Paracrine signaling

Paracrine signaling is a form of cell signaling or cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells altering the behaviour of those cells Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action) as opposed to cell signaling by endocrine factors hormones which travel considerably longer distances via

Interaction with adipocytes induces lung adenocarcinoma

The interaction between cancer cells and adipocytes in lung cancer progression remains unclear Although lung cancer is not considered to be associated with obesity previous studies have demonstrated that obesity induced by a high-fat diet increases cancer-associated mortality and the likelihood of lung carcinoma in mice ( 17 18 )

Utilization of adipocyte

Jun 18 2018The cancer cell-adipocyte interaction which induces lipolysis in adipocytes and enables transfer of FAs from adipocytes into cancer cells ultimately leading to β–oxidation in cancer cells has been demonstrated in acute myeloid leukemia ovarian and prostate carcinoma [5 14] The metabolic crosstalk between adipocytes and breast cancer

Breast cancer mammospheres secrete Adrenomedullin to

expression in adipocytes Conclusions: Breast tumor cells secreted ADM that modified cancer–associated adipocytes through paracrine signaling leading to metabolic changes and delipidation Hence ADM appears to be crucial in controlling the interactions between cancer cells and adipocytes and represents an excellent target to hinder them

Paracrine Interactions between Adipocytes and Tumor Cells

Paracrine Interactions between Adipocytes and Tumor Cells Recruit and Modify Macrophages to the Mammary Tumor Microenvironment: The Role of Obesity and Inflammation in Breast Adipose Tissue by Ana M Santander 1 Omar Lopez-Ocejo 1 Olivia Casas 1 Thais Agostini 1 Lidia Sanchez 1 Eduardo Lamas-Basulto 1 Roberto Carrio 1 Margot P

A Paracrine Loop Between Adipocytes and Macrophages

Because both adipocytes and macrophages are capable of secreting a number of biologically active substances it is important to identify the paracrine signals between adipocytes and macrophages Using an anti-TNF-α neutralizing antibody we successfully inhibited the upregulation of MCP-1 gene expression in 3T3-L1 cocultured with RAW264

Bone marrow adipocytes promote tumor growth in bone via

Nov 01 2013Whether we can use tumor-adipocyte co-dependence to therapeutically starve metastatic cancer cells in the bone marrow niche emerges as an attractive concept that warrants further studies As a mediator of lipid trafficking between adipocytes and tumor cells FABP4 itself may be a viable candidate for therapeutic targeting

Adipose Tissue

Adipose tissue when carried around in excessive amounts predisposes to a large number of diseases Epidemiological data show that the prevalence of obesity has significantly increased over the past 20 years and continues to do so at an alarming rate Here some molecular aspects of the key constituent of adipose tissue the adipocyte are reviewed

Hyperinsulinemia Induces Insulin Resistance on Glucose and

Human adipocyte secretion profile is regulated through differentiation paracrine interaction between fat and skeletal muscle When we explored the secretion pattern of LiSa-2 cells through the differentiation process adiponectin content in conditioned medium peak at 14 d followed by a decline on 21 d A different pattern of release was

An

Jun 14 2012Stromal–epithelial interactions play an integral role in regulating tumor development in the mammary gland 1 2 To address the complexity of these interactions the establishment of a 3D tissue culture model is essential for understanding the inter‐relationship between the epithelial cells and the breast stroma Previous evidence supports the vital role of the local environment in

Butyrate attenuates inflammation and lipolysis generated

Aim: Paracrine interaction between macrophages and adipocytes in obese visceral fat tissues is thought to be a trigger of chronic inflammation The immunomodulatory effect of the short chain fatty acid butyric acid has been demonstrated

Adipokines Toward the Molecular Dissection of Interactions

Dissection of Interactions Between Stromal Adipocytes and Breast Ca ncer Cells 81 proliferation pathways to promote tumor growth and development (Iyengar et al 2003) More recently fat tissue has been recognized as an important secretory organ that can produce various hormones cytokines and growth factors collectively called adipokines

Regucalcin enhances adipocyte differentiation and

Aug 11 2020Previously established in vitro coculture studies have reported that (a) the NF‐κB pathway is activated in both 3T3‐L1 adipocytes and RAW264 7 macrophages via paracrine interaction between the two cell types (b) NF‐κB activation in cocultured 3T3‐L1 adipocytes contributes to FFAs release and (c) the FFAs as 3T3‐L1 adipocyte

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